We assessed the clinical efficacy and safety of this new therapy. Uncontrolled studies suggest that multisite biventricular pacing improves hemodynamics and well-being by reducing ventricular asynchrony. One third of patients with chronic heart failure have electrocardiographic evidence of a major intraventricular conduction delay, which may worsen left ventricular systolic dysfunction through asynchronous ventricular contraction. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. Conclusions: Patients with IVCD may not respond to CRT, but LADEV at baseline and reversal of ventricular activation after CRT on surface ECG could be important to predict response to CRT.NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. Multivariable logistic regression analysis showed that LADEV at baseline, or ΔQRS and axis shift from LADEV to RADEV after CRT were independent predictors of response to CRT. 13%, P=0.003) were found more frequently in responders. 13%, P<0.001), and both rightward forces in lead I and anterior forces in V1 (56% vs. 7☒4ms, P=0.02), axis shift from LADEV to right axis deviation (RADEV 69% vs. After CRT, greater shortening of QRS duration (ΔQRS 26☒4 vs. 29%, P=0.004) compared with non-responders. 144☑8ms, P=0.02) and a higher frequency of left axis deviation (LADEV 75% vs. At baseline, responders had a wider QRS duration (158☑8 vs. Methods and Results: Among the cohort of 152 CRT patients, 40 patients with IVCD were evaluated. The purpose of this study was to investigate the benefits of CRT and significant variables on surface electrocardiogram (ECG) to predict response to CRT in those patients. Heart Failure, National Cerebral and Cardiovascular Centerĭepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Centerĭepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto Universityĭivisions of Arrhythmia and Electrophysiology, National Cerebral and Cardiovascular Center Department of Cardiovascular Medicine, Nippon Medical Schoolīackground: Little is known about predictors of response to cardiac resynchronization therapy (CRT) in patients with intraventricular conduction delay (IVCD). Divisions of Arrhythmia and Electrophysiology, National Cerebral and Cardiovascular Center
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